(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethan-1-one(IbrutinibImpurity)
98%
Reagent
Code: #231878
CAS Number
1288338-95-3
blur_circular Chemical Specifications
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Molecular Information
Weight
428.49 g/mol
Formula
C₂₄H₂₄N₆O₂
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Storage & Handling
Storage
Room temperature
description Product Description
This compound is a key impurity that occurs during the synthesis of ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor used to treat hematological malignancies such as chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). Used primarily as a reference standard in pharmaceutical quality control and analytical testing during ibrutinib production, it helps ensure the purity and consistency of the final drug product. It is instrumental in validating analytical methods, such as HPLC and mass spectrometry (including LC-MS), to detect and quantify impurities in ibrutinib formulations. Due to its structural similarity to the active pharmaceutical ingredient, it aids in studying degradation pathways and establishing stability profiles of ibrutinib under various storage conditions. Controlled levels of this impurity support compliance with regulatory guidelines for drug safety and efficacy.
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