Sulfosulfuron is primarily used as a selective herbicide in agriculture, especially in cereal crops such as wheat and barley. It controls a broad spectrum of broadleaf weeds and some grassy weeds by inhibiting the enzyme acetolactate synthase (ALS), which is essential for plant amino acid synthesis. Due to its low application rate and high efficacy, it is favored for post-emergence weed control. It is particularly useful in managing difficult-to-control weeds like wild oats, ryegrass, and mustards. Sulfosulfuron degrades relatively quickly in soil, reducing the risk of carryover to subsequent crops, making it suitable for use in rotation systems. Its selectivity allows crops to metabolize the herbicide safely while targeting unwanted vegetation.