Metrafenone is primarily used as a fungicide in agriculture, especially in the control of powdery mildew on a variety of crops such as grapes, cucurbits, and cereals. It is effective at low application rates and works both protectively and curatively by inhibiting fungal respiration. Its systemic and translaminar properties allow it to move within plant tissues, providing reliable coverage and longer-lasting protection. Due to its favorable environmental and toxicological profile, metrafenone is considered suitable for use in integrated pest management programs and is often applied in vineyards where repeated treatments are needed during the growing season.