Tri-n-butyltin trifluoromethanesulfonate is primarily used as a catalyst in organic synthesis. It is particularly effective in promoting esterification and transesterification reactions, where it helps in the formation of esters from carboxylic acids and alcohols. This compound is also utilized in the synthesis of complex organic molecules, including natural products and pharmaceuticals, due to its ability to facilitate carbon-carbon bond formation. Additionally, it finds application in the preparation of polymers and resins, where it acts as a curing agent or cross-linking agent, enhancing the material properties. Its strong Lewis acid character makes it valuable in various catalytic processes, including Friedel-Crafts alkylation and acylation reactions.