Used in pharmaceuticals as an intermediate in the synthesis of pyrimidine nucleotides, orotic acid plays a role in cell metabolism and is involved in the biosynthesis of RNA and DNA. It is studied for its potential in supporting liver function and in the treatment of certain metabolic disorders. Some dietary supplements include orotic acid or its salts, such as magnesium orotate, which are claimed to support heart health and energy metabolism, though scientific evidence remains limited. It is also used in research settings to investigate nucleotide metabolism and cellular transport mechanisms.