Used primarily in the synthesis of oligonucleotides, this chemical serves as a protecting group for the hydroxyl group in nucleosides. Its application is critical in the field of nucleic acid chemistry, where it helps in the stepwise construction of DNA sequences during solid-phase synthesis. The tert-butyldimethylsilyl (TBDMS) group provides stability to the nucleoside during the chemical reactions, ensuring that the desired sequence is accurately assembled. This compound is particularly valuable in the development of therapeutic oligonucleotides, such as antisense drugs and siRNA, where precise control over the molecular structure is essential for biological activity. Additionally, it is utilized in research settings for the study of DNA repair mechanisms and the synthesis of modified nucleosides with potential antiviral or anticancer properties.