Used as a key building block in medicinal chemistry, particularly in the development of bioactive molecules and pharmaceuticals. Its rigid bicyclic structure acts as a high-strain linker that can improve metabolic stability, membrane permeability, and target binding selectivity. Commonly employed in the synthesis of novel drug candidates, especially as a bioisostere for phenyl or tert-butyl groups to modulate physicochemical properties. Frequently utilized in fragment-based drug discovery and in the design of CNS-targeted compounds due to its favorable polarity and three-dimensional character. Also applied in the preparation of covalent inhibitors and PROTACs where spatial control and stability are critical.