ML-346 is primarily used in biochemical and pharmacological research as a selective activator of the mitochondrial pyruvate carrier (MPC). It plays a key role in studies related to cellular metabolism, particularly in understanding how pyruvate transport into mitochondria affects metabolic pathways. Researchers use ML-346 to modulate mitochondrial pyruvate uptake, which helps investigate metabolic diseases such as diabetes, cancer, and neurodegenerative disorders. Its ability to enhance MPC activity makes it a valuable tool for exploring the link between mitochondrial function and cellular energy homeostasis. Additionally, ML-346 is employed in drug development studies aiming to target metabolic dysregulation in various disease models.