3,4,5-Trimethoxy-N-(3-(7-methylimidazo[1,2-a]pyridin-2-yl)phenyl)benzamide

98%

Reagent Code: #215940
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CAS Number 708995-11-3

science Other reagents with same CAS 708995-11-3

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Weight 417.46 g/mol
Formula C₂₄H₂₃N₃O₄
inventory_2 Storage & Handling
Storage 2-8°C, sealed, dry

description Product Description

Used in pharmaceutical research as a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK9, which plays a key role in transcription regulation. This compound shows promise in oncology for disrupting cancer cell proliferation by inhibiting RNA polymerase II phosphorylation, thereby suppressing the expression of anti-apoptotic proteins like Mcl-1. It is investigated for its antitumor activity in hematological malignancies, including leukemia and lymphoma. Its imidazopyridine core enhances binding affinity and selectivity, making it a valuable scaffold in developing targeted cancer therapies. Also employed as a chemical probe to study transcriptional control in cellular models.

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Size Availability Unit Price Quantity
inventory 10mg
10-20 days ฿6,930.00
inventory 25mg
10-20 days ฿13,860.00
inventory 50mg
10-20 days ฿23,540.00

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3,4,5-Trimethoxy-N-(3-(7-methylimidazo[1,2-a]pyridin-2-yl)phenyl)benzamide
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Used in pharmaceutical research as a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK9, which plays a key role in transcription regulation. This compound shows promise in oncology for disrupting cancer cell proliferation by inhibiting RNA polymerase II phosphorylation, thereby suppressing the expression of anti-apoptotic proteins like Mcl-1. It is investigated for its antitumor activity in hematological malignancies, including leukemia and lymphoma. Its imidazopyridine

Used in pharmaceutical research as a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK9, which plays a key role in transcription regulation. This compound shows promise in oncology for disrupting cancer cell proliferation by inhibiting RNA polymerase II phosphorylation, thereby suppressing the expression of anti-apoptotic proteins like Mcl-1. It is investigated for its antitumor activity in hematological malignancies, including leukemia and lymphoma. Its imidazopyridine core enhances binding affinity and selectivity, making it a valuable scaffold in developing targeted cancer therapies. Also employed as a chemical probe to study transcriptional control in cellular models.

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