(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide hydrate

≥99.8%

Reagent Code: #184681
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CAS Number 1042385-75-0

science Other reagents with same CAS 1042385-75-0

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 487.95 g/mol
Formula C₂₄H₂₇ClFN₅O₃
badge Registry Numbers
MDL Number MFCD19443734
inventory_2 Storage & Handling
Storage -20°C, dry, sealed

description Product Description

Used in targeted cancer therapies, particularly in the treatment of non-small cell lung cancer (NSCLC). It functions as an irreversible inhibitor of the epidermal growth factor receptor (EGFR), including mutant forms such as T790M and exon 19 deletions, which are associated with tumor growth and resistance to earlier-generation drugs. By selectively blocking EGFR signaling pathways, it suppresses cancer cell proliferation and promotes apoptosis. Its irreversible binding enhances potency and duration of action, making it effective in patients who have developed resistance to other EGFR inhibitors. The compound is designed for oral administration and has shown clinical efficacy in reducing tumor size and improving progression-free survival in advanced stages of the disease.

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Size Availability Unit Price Quantity
inventory 250mg
10-20 days ฿990.00
inventory 1g
10-20 days ฿5,000.00
inventory 5g
10-20 days ฿18,000.00

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(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide hydrate
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Used in targeted cancer therapies, particularly in the treatment of non-small cell lung cancer (NSCLC). It functions as an irreversible inhibitor of the epidermal growth factor receptor (EGFR), including mutant forms such as T790M and exon 19 deletions, which are associated with tumor growth and resistance to earlier-generation drugs. By selectively blocking EGFR signaling pathways, it suppresses cancer cell proliferation and promotes apoptosis. Its irreversible binding enhances potency and duration of a

Used in targeted cancer therapies, particularly in the treatment of non-small cell lung cancer (NSCLC). It functions as an irreversible inhibitor of the epidermal growth factor receptor (EGFR), including mutant forms such as T790M and exon 19 deletions, which are associated with tumor growth and resistance to earlier-generation drugs. By selectively blocking EGFR signaling pathways, it suppresses cancer cell proliferation and promotes apoptosis. Its irreversible binding enhances potency and duration of action, making it effective in patients who have developed resistance to other EGFR inhibitors. The compound is designed for oral administration and has shown clinical efficacy in reducing tumor size and improving progression-free survival in advanced stages of the disease.

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