6-Amino-2-(butylamino)-9-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)methyl)-7,9-dihydro-8H-purin-8-one
98%
Reagent
Code: #139036
CAS Number
1059070-10-8
blur_circular Chemical Specifications
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Molecular Information
Weight
400.48 g/mol
Formula
C₁₉H₂₈N₈O₂
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Registry Numbers
MDL Number
MFCD30182245
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Storage & Handling
Storage
2-8°C, Sealed, Dry, Light-proof, Inert Gas
description Product Description
Used in research as a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK9, which plays a key role in transcription regulation. This compound is valuable in studying cancer cell proliferation and survival, especially in hematological malignancies. It shows promise in disrupting oncogenic transcription by targeting the CDK9/cyclin T complex, leading to downregulation of short-lived oncoproteins like Mcl-1. Due to its ability to penetrate cells and modulate transcriptional pathways, it is widely applied in preclinical studies for anticancer drug development. Its structural features allow for high selectivity, reducing off-target effects in cellular assays.
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