tert-Butyl 4-bromoisoindoline-2-carboxylate
95%
Reagent
Code: #145540
CAS Number
1035235-27-8
blur_circular Chemical Specifications
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Molecular Information
Weight
298.18 g/mol
Formula
C₁₃H₁₆BrNO₂
thermostat
Physical Properties
Boiling Point
363.2°C
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Storage & Handling
Storage
2-8°C
description Product Description
Used as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of kinase inhibitors and other bioactive molecules. Its protected amine and bromo-functionalized isoindoline core allow for selective cross-coupling reactions and further derivatization, making it valuable in medicinal chemistry for constructing complex heterocyclic systems. Commonly employed in solid-phase and solution-phase peptide-like synthesis due to the stability and ease of deprotection of the tert-butyl carbamate (Boc) group. Also utilized in the preparation of proteolysis-targeting chimeras (PROTACs) and other targeted therapeutics.
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