Cupric citrate is widely used as a source of copper in nutritional supplements, fortified foods, and multivitamin products due to its relatively high bioavailability, low toxicity, and good solubility compared to other copper salts. It serves as a micronutrient additive in animal feed, helping prevent copper deficiency which supports proper enzyme function, iron metabolism, and overall growth.

In agriculture, cupric citrate acts as a fungicide and micronutrient in crop treatments, especially in organic farming, where it aligns with regulations permitting natural chelated metals. Its chelated form enhances stability and uptake in plants, reducing leaching and improving effectiveness.

It is also employed in analytical chemistry as a reagent, particularly in tests for reducing sugars and in certain enzyme assays where copper ions are required in a soluble, controlled-release form.

In industrial applications, cupric citrate finds use in electroplating baths and as a catalyst precursor in organic synthesis, where the citrate ligand helps control the release of copper ions and improves solution stability. It is sometimes used as a catalyst or additive in chemical processes, such as the synthesis of copper-containing nanomaterials.

In the cosmetics and personal care industry, cupric citrate is incorporated into skin creams and lotions for its antioxidant properties and ability to stimulate collagen production.

Emerging research explores its use in medical applications, such as in biomaterials that provide slow-release copper for wound healing and promoting new blood vessel formation (angiogenesis).