(S)-3-Cyclopentyl-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile (2S,3S)-2,3-bis(benzoyloxy)succinate

95%

Reagent Code: #232650
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CAS Number 2920037-87-0

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 794.92 g/mol
Formula C₄₁H₄₆N₆O₉Si
inventory_2 Storage & Handling
Storage 2-8°C, Inert Gas

description Product Description

Used in the synthesis of antiviral agents, specifically as a key intermediate in the production of non-nucleoside NS5A inhibitors for the treatment of hepatitis C virus (HCV) infections, such as ledipasvir. The compound features a protected 7H-pyrrolo[2,3-d]pyrimidin-4-yl core linked to a 1H-pyrazol-1-yl group and a cyclopentyl propanenitrile moiety, with a SEM (2-(trimethylsilyl)ethoxy)methyl protecting group on the pyrrole nitrogen. It is provided as the (2S,3S)-2,3-bis(benzoyloxy)succinate salt to ensure the (S) stereochemistry at the chiral center. This intermediate enables selective deprotection and coupling in multi-step synthetic routes, valuable in medicinal chemistry for developing drug candidates with enhanced potency, metabolic stability, and pharmacokinetic profiles.

shopping_cart Available Sizes & Pricing

Size Availability Unit Price Quantity
inventory 50mg
10-20 days ฿13,420.00
inventory 100mg
10-20 days ฿22,740.00
inventory 250mg
10-20 days ฿38,560.00

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