Indolizine derivatives are primarily used in pharmaceutical research due to their biological activity. They serve as key scaffolds in the development of new drug candidates, especially in anti-inflammatory, antimicrobial, and anticancer agents. Their structural similarity to naturally occurring alkaloids makes them valuable in designing compounds that interact with enzymes and receptors in the human body. Additionally, indolizine cores are explored in medicinal chemistry for their potential neuroprotective and antiviral properties. In materials science, these compounds are investigated for their fluorescent properties, which can be utilized in organic light-emitting diodes (OLEDs) and sensors.