Used as a key intermediate in the synthesis of kinase inhibitors, particularly in the development of anticancer agents. Its structure allows selective binding to ATP sites in protein kinases, making it valuable in targeted therapies for cancers such as leukemia and non-small cell lung cancer. Also employed in the preparation of JAK2 and EGFR inhibitors. Commonly modified at the 4-chloro and 2-amino positions to enhance potency, selectivity, and pharmacokinetic properties in drug candidates. Widely utilized in medicinal chemistry research for structure-activity relationship (SAR) studies.