Used as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of kinase inhibitors for cancer treatment. The 1-((2-(Trimethylsilyl)ethoxy)methyl) (SEM) group acts as a stable protecting group for the indazole nitrogen, removable under mild acidic conditions for precise multi-step synthesis control. Its functional groups, including bromine at the 5-position and iodine at the 3-position, enable selective cross-coupling reactions, making it valuable in medicinal chemistry for constructing complex heterocyclic systems. Commonly employed in research settings to design potent and selective bioactive molecules, especially in targeted therapies. Also utilized in the preparation of radiolabeled analogs for imaging studies due to the presence of bromine and iodine atoms.