G-1 is widely used in scientific research, particularly in the field of cell biology and pharmacology. It serves as a selective agonist for the G protein-coupled estrogen receptor (GPER), which is involved in various physiological processes. Researchers utilize G-1 to study the role of GPER in cancer progression, cardiovascular function, and metabolic regulation. Its application extends to experiments aimed at understanding estrogen signaling pathways independent of classical estrogen receptors. Additionally, G-1 is employed in drug development to explore potential therapeutic targets for conditions such as breast cancer, hypertension, and diabetes. Its specificity makes it a valuable tool for dissecting the complex mechanisms of GPER-mediated effects in different tissues.