6-Iodoquinazoline is primarily used as an intermediate in the synthesis of biologically active compounds, especially in pharmaceutical research. Its key application lies in the development of kinase inhibitors, which are important in targeted cancer therapies. The iodine atom allows for further functionalization through cross-coupling reactions, such as Suzuki or Heck reactions, enabling the construction of complex quinazoline derivatives. These derivatives are explored for their antitumor, antiviral, and anti-inflammatory properties. It is also employed in the preparation of receptor tyrosine kinase inhibitors, particularly targeting EGFR (epidermal growth factor receptor), making it valuable in oncology drug discovery. Additionally, its structure serves as a scaffold in medicinal chemistry for optimizing potency and selectivity in new drug candidates.