Fumonisin B2 is primarily associated with contamination in agricultural products, especially corn and corn-based foods. It is a mycotoxin produced by certain species of Fusarium fungi, and its presence poses significant health risks rather than offering beneficial applications. Due to its toxicological profile, it is not used commercially or industrially as a functional chemical. The main concern with Fumonisin B2 lies in its impact on food safety and animal health. It has been linked to various adverse effects in livestock, including liver and kidney damage, particularly in horses and pigs. In poultry, it can reduce weight gain and impair immune function. In humans, chronic exposure to Fumonisin B2 is a health concern due to its potential carcinogenicity, especially in relation to esophageal cancer. It also interferes with sphingolipid metabolism, which can disrupt cell signaling and lead to tissue damage. Regulatory agencies monitor levels of Fumonisin B2 in food and feed to minimize exposure. Its "application" is thus limited to being a marker for fungal contamination, guiding quality control in grain storage, processing, and food production. Preventing its accumulation through proper agricultural practices and storage is critical in ensuring food safety.