Used as a reference standard in analytical laboratories for the identification and quantification of caryophyllene oxide in essential oils, plant extracts, and cannabis samples. Commonly applied in quality control and research settings involving gas chromatography (GC) or high-performance liquid chromatography (HPLC). Helps ensure accuracy in profiling terpenes for fragrance, flavor, and pharmaceutical studies. Also utilized in environmental and biological testing to detect terpene derivatives in air or biological matrices.