Atalantoflavone exhibits significant anti-inflammatory and antioxidant properties, making it a compound of interest in pharmaceutical and nutraceutical research. It has been studied for its potential to inhibit pro-inflammatory cytokines and enzymes such as COX-2 and LOX, suggesting possible use in managing inflammatory diseases like arthritis and asthma. Its antioxidant activity helps protect cells from oxidative stress, which is linked to neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease, indicating neuroprotective potential. Atalantoflavone can cross the blood-brain barrier, further supporting its role in brain health. Additionally, atalantoflavone shows antimicrobial activity against certain pathogens, supporting its traditional use in treating infections. Ongoing research explores its role in cancer prevention due to its ability to induce apoptosis and suppress tumor cell proliferation. These diverse biological activities position atalantoflavone as a promising candidate for drug development and functional health products.