Used primarily in research to inhibit fatty acid oxidation by targeting carnitine palmitoyltransferase-1 (CPT-1), etomoxir is applied in studies related to metabolism, particularly in cancer, diabetes, and cardiovascular diseases. It helps investigate how cells shift energy sources between fatty acids and glucose. In cancer research, etomoxir is used to explore metabolic vulnerabilities in tumor cells. In cardiac studies, it has been examined for potential effects on heart muscle efficiency under stress. It also serves as a tool compound in metabolic phenotyping of cells and tissues.