Ammonium bifluoride is widely used in industrial cleaning and etching processes. It is particularly effective for cleaning metal surfaces, removing oxides, and preparing surfaces for further treatment. In the glass and ceramics industries, it is used for frosting and etching to create decorative patterns or to improve adhesion for coatings.

In the electronics industry, it plays a crucial role in cleaning and etching silicon wafers during semiconductor manufacturing. It is also utilized in the petroleum industry for acidizing oil wells to enhance production by dissolving rock formations.

Additionally, it serves as a precursor in the synthesis of other fluorine compounds, such as aluminum fluoride. It can be a component in electrolyte solutions for certain metal plating processes. Its ability to release hydrofluoric acid makes it valuable in various chemical processes, though it requires careful handling due to its corrosive nature.