Penicillinase is widely used in the medical and pharmaceutical fields to combat antibiotic resistance. It is an enzyme that breaks down penicillin antibiotics, rendering them ineffective. This property is utilized in laboratory settings to test the susceptibility of bacteria to penicillin-based drugs. By adding penicillinase to bacterial cultures, researchers can determine if the bacteria produce the enzyme themselves, indicating resistance to penicillin. Additionally, penicillinase is employed in the development of combination therapies, where it is paired with penicillin antibiotics to protect against degradation by resistant bacteria. This helps enhance the efficacy of the treatment in patients with penicillin-resistant infections. In diagnostic kits, penicillinase is used to detect the presence of beta-lactam antibiotics in samples, ensuring accurate analysis in clinical and research environments. It is also applied in pharmaceutical manufacturing to eliminate penicillin residues from biological samples, ensuring products are free from antibiotic contaminants.