Fumarase is an enzyme that plays a critical role in the Krebs cycle, also known as the citric acid cycle, which is essential for cellular energy production. In medical research, human fumarase is studied for its involvement in metabolic disorders, particularly fumarase deficiency, a rare genetic condition that leads to severe neurological and developmental issues. Understanding its function helps in developing potential therapeutic strategies for such diseases. Additionally, fumarase is utilized in biochemical studies to investigate mitochondrial function and metabolic pathways, providing insights into cellular respiration and energy metabolism. Its application extends to biotechnological processes, where it is used in the production of organic acids and other metabolites.