Colipase is essential in the digestion of dietary fats, particularly in the small intestine. It works by binding to pancreatic lipase and anchoring it to the surface of lipid droplets, especially in the presence of bile salts which can otherwise inhibit lipase activity. This interaction ensures efficient breakdown of triglycerides into free fatty acids and glycerol, facilitating fat absorption in the gut. Due to its role in fat digestion, colipase is studied in the context of pancreatic insufficiency and digestive disorders, and it may be considered in enzyme replacement therapies to improve nutrient absorption in patients with compromised pancreatic function.