SET2 is widely utilized in the field of epigenetics and molecular biology, particularly in the study of histone modifications. It plays a crucial role in the methylation of histone H3 at lysine 36 (H3K36me), a key epigenetic mark associated with transcriptional regulation and DNA repair processes. Researchers leverage SET2 to investigate its involvement in gene expression, chromatin structure, and cellular differentiation. Additionally, it is employed in the development of therapeutic strategies targeting epigenetic dysregulation in diseases such as cancer, where aberrant histone methylation patterns are often observed. Its application extends to synthetic biology, where it is used to engineer chromatin states for functional genomics studies.