SGC-0946 is a potent and selective inhibitor of the protein arginine methyltransferase PRMT6. It is primarily used in epigenetic research to study the role of PRMT6 in gene regulation, DNA repair, and cellular differentiation. Due to its high selectivity, SGC-0946 helps scientists dissect the biological functions of PRMT6 without significantly affecting other PRMT family members. It has been employed in cellular assays to reduce asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a), a mark associated with transcriptional repression. This compound is valuable in cancer research, where PRMT6 overexpression has been linked to tumorigenesis, particularly in lung and liver cancers. SGC-0946 serves as a tool compound for validating PRMT6 as a therapeutic target and supports the development of novel epigenetic therapies.