Used as a derivatizing agent in analytical chemistry to enhance the detection and quantification of various compounds, particularly in gas chromatography and mass spectrometry. It reacts with target analytes to form stable, volatile derivatives, improving sensitivity and selectivity. Commonly applied in environmental analysis to detect trace levels of pollutants, such as phenols, carboxylic acids, and amines, in water, soil, and air samples. Also utilized in pharmaceutical research for the analysis of drug metabolites and in forensic toxicology to identify and measure substances in biological samples. Its pentafluorobenzyl group provides excellent electron-capturing properties, making it suitable for electron capture detection methods.

Additionally, it serves as a key intermediate in the synthesis of various fluorinated compounds in the chemical industry, particularly for agrochemicals and pharmaceuticals, where the pentafluorobenzyl group enhances product stability and performance.