Widely used as a derivatizing agent in analytical chemistry, particularly in gas chromatography (GC) and mass spectrometry (MS) applications. It enhances the detection and quantification of various compounds, such as carboxylic acids, phenols, and amines, by converting them into more volatile and easily analyzable derivatives. Commonly employed in environmental analysis to detect trace levels of pollutants in water, soil, and air samples. Also utilized in pharmaceutical research for the analysis of drug metabolites and impurities. Its strong electron-withdrawing fluorine atoms improve sensitivity and selectivity in analytical methods. Additionally, it serves as a key reagent in organic synthesis for introducing pentafluorobenzyl groups into target molecules.