Used in topical treatment of actinic keratosis, a precancerous skin condition caused by sun damage. The compound works by inducing cell death in abnormal skin cells and promoting an inflammatory response that helps clear the lesions. It is applied as a gel formulation over affected areas, typically on the face or scalp, for a short-duration treatment regimen. Its mechanism involves activation of protein kinase C, leading to rapid lesion necrosis and clearance. Due to its potent biological activity, it is used in low concentrations to minimize skin irritation while maintaining efficacy.