GNE-6641 is primarily utilized in the field of cancer research, where it serves as a potent and selective inhibitor of ubiquitin-specific protease 7 (USP7). This enzyme plays a critical role in regulating the stability and function of key proteins involved in tumor suppression and oncogenesis. By inhibiting USP7, GNE-6641 disrupts the degradation pathway of tumor suppressor proteins, leading to their accumulation and subsequent activation of anti-tumor responses. This mechanism makes it a valuable tool for studying the role of USP7 in cancer biology and for exploring potential therapeutic strategies targeting protein degradation pathways. Additionally, GNE-6641 is used in preclinical studies to evaluate its efficacy in various cancer models, providing insights into its potential as a novel anti-cancer agent. Its selectivity and potency also make it a useful compound for probing the broader biological functions of USP7 in cellular processes beyond cancer.