Used as a derivatization reagent in analytical chemistry, particularly in gas chromatography and mass spectrometry, to enhance the volatility and thermal stability of polar compounds such as carboxylic acids and alcohols. Its strong electron-withdrawing pentafluoropropionyl group improves detection sensitivity in electron capture and negative chemical ionization mass spectrometry due to the high fluorine content. Commonly employed in environmental and pharmaceutical analysis for trace-level detection of acidic contaminants and metabolites. Also serves as a reagent in organic synthesis for introducing fluorinated acyl groups, which can influence the metabolic stability and lipophilicity of bioactive molecules.