Chlorotrimethylsilane (TMCS)

99.0%, MkSeal

Reagent Code: #159070
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CAS Number 75-77-4

science Other reagents with same CAS 75-77-4

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 108.64 g/mol
Formula C₃H₉ClSi
badge Registry Numbers
EC Number 200-900-5
MDL Number MFCD00000502
inventory_2 Storage & Handling
Storage 2-8℃, drying, inert gas storage

description Product Description

Used as a silylating agent in organic synthesis to protect hydroxyl, carboxyl, and amino groups by converting them into trimethylsilyl ethers or esters. This protection is reversible and helps stabilize sensitive functional groups during multi-step reactions. Commonly employed in the preparation of derivatives for gas chromatography and mass spectrometry to improve volatility and detection of polar compounds. Also serves as a reagent in the synthesis of silicon-based polymers and as a moisture scavenger in silicone sealants and adhesives. Plays a role in the production of pharmaceuticals and agrochemicals where selective protection is required.

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Size Availability Unit Price Quantity
inventory 100ml
10-20 days ฿1,860.00
inventory 500ml
10-20 days ฿4,150.00
inventory 1L
10-20 days ฿6,920.00
inventory 12X500ml
10-20 days ฿49,000.00

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Chlorotrimethylsilane (TMCS)
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Used as a silylating agent in organic synthesis to protect hydroxyl, carboxyl, and amino groups by converting them into trimethylsilyl ethers or esters. This protection is reversible and helps stabilize sensitive functional groups during multi-step reactions. Commonly employed in the preparation of derivatives for gas chromatography and mass spectrometry to improve volatility and detection of polar compounds. Also serves as a reagent in the synthesis of silicon-based polymers and as a moisture scavenger

Used as a silylating agent in organic synthesis to protect hydroxyl, carboxyl, and amino groups by converting them into trimethylsilyl ethers or esters. This protection is reversible and helps stabilize sensitive functional groups during multi-step reactions. Commonly employed in the preparation of derivatives for gas chromatography and mass spectrometry to improve volatility and detection of polar compounds. Also serves as a reagent in the synthesis of silicon-based polymers and as a moisture scavenger in silicone sealants and adhesives. Plays a role in the production of pharmaceuticals and agrochemicals where selective protection is required.

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