(R)-1-Methyl-4-hydroxy-L-proline methyl ester is primarily used in the synthesis of pharmaceuticals, particularly in the development of drugs targeting collagen-related disorders. It serves as a key intermediate in the production of compounds that inhibit prolyl hydroxylase enzymes, which are involved in collagen biosynthesis. This makes it valuable in the treatment of conditions like fibrosis, where excessive collagen deposition occurs. Additionally, it is utilized in the preparation of peptidomimetics, which are peptide-like molecules designed to mimic the structure and function of natural peptides, aiding in drug discovery for various diseases. Its role in chiral synthesis also makes it important for creating enantiomerically pure compounds, ensuring higher efficacy and specificity in therapeutic applications.