(E)-4-Hydroxychalcone is primarily utilized in the field of medicinal chemistry due to its bioactive properties. It has been studied for its potential anti-inflammatory and antioxidant effects, making it a candidate for developing therapeutic agents to treat inflammatory diseases and oxidative stress-related conditions. Additionally, it is explored for its role in cancer research, where it has shown promise in inhibiting the growth of certain cancer cells by inducing apoptosis and suppressing tumor progression. In cosmetic formulations, it is sometimes incorporated for its skin-lightening and anti-aging properties, as it can inhibit melanin production and reduce oxidative damage to the skin. Furthermore, it serves as a key intermediate in organic synthesis for producing more complex bioactive molecules.