Amikacin is widely used as an antibiotic in the treatment of severe bacterial infections, particularly those caused by Gram-negative bacteria. It is effective against infections such as pneumonia, septicemia, and infections of the urinary tract, abdomen, and central nervous system. Due to its broad-spectrum activity, it is often employed when other antibiotics have failed or when the specific bacteria are resistant to other treatments. It is commonly administered intravenously or intramuscularly in hospital settings, especially for critically ill patients. Additionally, it is used in combination with other antibiotics to enhance its efficacy and reduce the risk of resistance development. Amikacin is also utilized in the management of tuberculosis caused by multidrug-resistant strains of Mycobacterium tuberculosis. Its use requires careful monitoring due to potential side effects, including kidney toxicity and hearing loss.