Mupirocin is primarily used as a topical antibiotic to treat skin infections caused by bacteria, such as impetigo, folliculitis, and infected wounds. It is particularly effective against Staphylococcus aureus and Streptococcus pyogenes. The ointment form is applied directly to the affected area, helping to eliminate bacterial growth and promote healing. In nasal formulations, it is used to eradicate methicillin-resistant Staphylococcus aureus (MRSA) colonization in the nasal passages, reducing the risk of infection spread in healthcare settings. Its targeted action and minimal systemic absorption make it a safe and effective option for localized bacterial infections.