Methotrexate is widely used in the treatment of various types of cancer, including leukemia, lymphoma, breast cancer, and gestational trophoblastic disease, due to its ability to inhibit the growth of cancer cells. It is also a key medication in managing autoimmune diseases such as rheumatoid arthritis, psoriasis, and Crohn's disease, where it helps to reduce inflammation and slow disease progression. In addition, Methotrexate is utilized in the treatment of ectopic pregnancies and as a part of chemotherapy regimens. Its immunosuppressive properties make it valuable in preventing organ transplant rejection. The drug is administered in various forms, including oral tablets, injections, and intravenous infusions, depending on the condition being treated.