4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl
10mM in DMSO
Reagent
Code: #216305
CAS Number
57852-57-0
blur_circular Chemical Specifications
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Molecular Information
Weight
533.95 g/mol
Formula
C₂₆H₂₇NO₉·HCl
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Registry Numbers
MDL Number
MFCD00866457
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Storage & Handling
Storage
-20°C
description Product Description
Used in cancer research as an anthracycline antibiotic with antitumor activity. It functions by intercalating into DNA and inhibiting topoisomerase II, leading to DNA damage and apoptosis in cancer cells. Studied for its potential in treating various malignancies, particularly leukemia and solid tumors. Due to structural similarity to daunorubicin, it serves as a metabolite and analog in pharmacokinetic and structure-activity relationship studies. Also investigated for reduced cardiotoxicity compared to other anthracyclines, making it a candidate for developing safer chemotherapy agents.
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