Used to treat homozygous familial hypercholesterolemia (HoFH), a rare genetic disorder causing dangerously high levels of LDL cholesterol. It works by inhibiting a key protein involved in fat absorption in the intestines and cholesterol production in the liver. By reducing the body’s ability to produce and absorb fats, including cholesterol, it significantly lowers LDL cholesterol levels in patients who do not respond well to standard therapies. Typically prescribed alongside a low-fat diet and other lipid-lowering treatments. Requires careful monitoring due to risk of liver injury and fat accumulation in the liver.