2-Keto-D-gluconic acid hemicalcium salt hydrate is widely utilized in the food industry as a food additive, primarily for its role as a sequestrant and stabilizer. It helps in maintaining the quality and consistency of various food products by binding metal ions that could otherwise catalyze oxidation or spoilage. In the pharmaceutical sector, it serves as an intermediate in the synthesis of active pharmaceutical ingredients, particularly in the production of ascorbic acid (vitamin C). Additionally, it is employed in biotechnology and fermentation processes as a substrate or intermediate for producing other valuable biochemicals. Its ability to act as a chelating agent also makes it useful in industrial applications, such as water treatment, where it helps in controlling metal ion concentrations.