DEAE Dextran is widely used in molecular biology and biochemistry for its ability to facilitate the introduction of nucleic acids into cells, a process known as transfection. It is particularly effective in enhancing the uptake of DNA or RNA by cells, making it a valuable tool in genetic research and gene therapy.

Additionally, DEAE Dextran is employed in the purification of proteins, enzymes, and nucleic acids, where it aids in precipitation and separation of molecules based on their charge.

Its application extends to vaccine development, where it serves as an adjuvant to boost the immune response. In cell culture, it is used to improve cell adhesion and growth, supporting various experimental and industrial processes. Furthermore, DEAE Dextran is utilized in tissue engineering as a scaffold for three-dimensional cell structures and in drug delivery systems due to its biocompatibility and ability to enable controlled drug release.