2-Methoxyestradiol is primarily investigated for its potential therapeutic applications in cancer treatment. It has shown promise as an anti-angiogenic agent, inhibiting the formation of new blood vessels that tumors need to grow. This makes it a candidate for targeting various cancers, including breast, prostate, and ovarian cancers. Additionally, it exhibits anti-proliferative effects, directly hindering the growth of cancer cells. Beyond oncology, it is being studied for its potential in treating cardiovascular diseases due to its ability to reduce oxidative stress and inflammation. Its role in neurodegenerative diseases is also under exploration, as it may offer neuroprotective benefits. Research continues to uncover its full therapeutic potential and mechanisms of action.