Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid is primarily used in the field of medicinal chemistry and drug design. Its unique structure, featuring a strained bicyclic system, makes it a valuable bioisostere for aromatic rings and other rigid frameworks. This property allows it to improve the pharmacokinetic and pharmacodynamic profiles of drug molecules. It is often incorporated into compounds to enhance metabolic stability, reduce toxicity, and increase selectivity for target proteins. Additionally, its compact and rigid geometry is useful in the development of peptidomimetics and other biologically active molecules, where it can mimic specific spatial arrangements of functional groups. Its applications extend to materials science, where it is explored for creating novel polymers with unique mechanical and thermal properties.