15(S)-HEPE, or 15(S)-hydroxyeicosapentaenoic acid, is a specialized lipid mediator and metabolite derived from the omega-3 fatty acid eicosapentaenoic acid (EPA). It is primarily studied for its role in anti-inflammatory processes and its potential therapeutic applications in managing inflammatory diseases. It is known to modulate the immune response by influencing the production of pro-inflammatory and anti-inflammatory mediators. Research suggests that it may be beneficial in conditions such as arthritis, asthma, and other chronic inflammatory disorders. Additionally, 15(S)-HEPE is being explored for its effects on cardiovascular health, particularly in reducing the risk of atherosclerosis by improving endothelial function and reducing oxidative stress. Its role in cancer prevention and treatment is also under investigation, as it may inhibit tumor growth and promote apoptosis in cancer cells. Furthermore, 15(S)-HEPE is of interest in the field of dermatology for its potential to improve skin health by reducing inflammation and promoting healing in conditions like psoriasis and eczema.