Methylpentafluorobenzoate is widely used as a derivatization agent in analytical chemistry, particularly in gas chromatography and mass spectrometry. It helps in enhancing the detection and quantification of various compounds by converting them into more volatile and stable derivatives. This chemical is also employed in the synthesis of pharmaceuticals and agrochemicals, where it serves as an intermediate in the production of complex molecules. Additionally, its fluorinated structure makes it valuable in materials science for developing specialty polymers and coatings with unique properties such as high thermal stability and chemical resistance. In research, it is utilized in studies involving fluorine chemistry and the development of novel fluorinated compounds.