Azide-PEG2-Ms is widely used in bioconjugation and chemical biology for attaching azide-functionalized molecules to various substrates. Its PEG spacer enhances solubility and reduces steric hindrance, making it ideal for click chemistry reactions, particularly copper-catalyzed azide-alkyne cycloaddition (CuAAC). This compound is commonly employed in the synthesis of drug delivery systems, bioconjugates, and labeled biomolecules for imaging and diagnostics. It is also utilized in surface modification and functionalization of nanoparticles, polymers, and biomaterials to introduce azide groups for further chemical modifications. Additionally, it plays a role in proteomics and glycobiology for tagging and studying complex biological molecules.