1-Bromo-2-(difluoromethoxy)benzene
≥97.0%
Reagent
Code: #143614
CAS Number
175278-33-8
blur_circular Chemical Specifications
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Molecular Information
Weight
223.02 g/mol
Formula
C₇H₅BrF₂O
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Registry Numbers
MDL Number
MFCD00221468
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Physical Properties
Boiling Point
85 °C
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Storage & Handling
Density
1.582
Storage
Room temperature
description Product Description
Used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, particularly in reactions where a brominated aromatic ring is needed for coupling processes such as Suzuki or Heck reactions. Its difluoromethoxy group contributes to enhanced metabolic stability and lipophilicity in bioactive molecules, making it valuable in the development of new drug candidates. Commonly employed in medicinal chemistry for structure-activity relationship (SAR) studies due to the electron-withdrawing nature of the difluoromethoxy substituent. Also utilized in the preparation of fluorinated analogs of natural products and biologically active compounds.
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